Application of urokinase in the treatment of thrombosed permanent catheter of dialysis patient
HUN Wai Chan, AO Ieng Chi Wa, TSAI Tsung Yang, IONG Iok In, XIAO Hong
Departmemt of Internal Medicine, Kiang Wu Hospital. Macau
Objective Retrospectively study the thrombolytic effect of urokinase in the treatment of thrombosed permanent catheter of dialysis patients.
Methods Diluted urokinase (5000iu/ml) was instilled in thrombosed catheter for 30-60min, observed the change of arterial lumen blood flow and venous pressure in venous lumen during dialysis before and after the thrombolytic treatment. Side effects of the treatment were also recorded.
Results Of 20 cases with 61 times and 70 lumens of thrombolytic treatments, 78.33% arterial lumen restored sufficient blood flow and 90% venous lumen pressure dropped to normal range to ensure an effective and fluent dialysis. The overall successful rate of thrombolytic treatment was 80%. No complication was recorded.
Conclusion Intracatheter thrombolysis treatment with urokinase is highly effective and safe in restoring the patency of occluded permanent catheter among hemodialysis patients.
[Key Words] Urokinase; Hemodialysis; Permanent Catheter